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GLP-1 Agonists and Weight Loss Therapy - Efficacy and The Side Effects

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 Editors Note: Please see update of 10.9.26 for recent developments, including Retatrutide --------------------------- Weight loss therapies using GLP-1 agonists have been implicated in the news recently as having a tendency to cause gallstones, and in some cases more serious gall-bladder damage. A recent report confirmed that there has been a marked rise in gall-bladder removals in UK over the last few years, and MHRA have recently updated their guidance on weight loss jabs. Should we have expected this, and what might be the consequences ? The short answer to this question is …Yes - this particular side effect was predictable, particularly after longer-term exposure..... To explain this more fully, we first need a little background. GLP-1 agonists are one of the most successful weight-loss inducing agents produced by Big Pharma of recent times; they have already generated a level of demand in the otherwise healthy population which far outstrips the available supply. Orig...
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Advanced Search Query Builder: The Easy Way to do Selective Internet Searches

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  Ever wanted to get rid of those pesky AI summaries that seem to appear every time you do a Google search ? Want to bypass AI and 'do your own thing' with a more focussed advance internet search ? Now you can - and without needing to remember the exact query syntax to use....or switching search engines. To find out how, just read on….. Background Internet searching has changed a lot over the last few years, due largely to the automatic introduction of Artificial Intelligence (AI) agents into everything but the most basic searches by the all the major search engine providers. There is no doubt that those AI summaries which appear uninvited in response to most queries can be very useful, particularly for those who know little about a particular subject to start with and aren’t quite sure where to start looking. But they aren't always needed, and they can clutter up the results presentation and slow things down if you already know what you’re looking for, and want ...
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Travelodge: The New ‘Blind Date’ Scheme

  Followers of the now somewhat notorious hotel chain may have noted an item in the news recently regarding several instances of occupied room keys being issued in error to unauthorised persons. Rumours abound as to why this might have happened, citing lax hotel security policy, poor staff training, etc. However, an interesting alternative explanation surfaced recently on social media, based on the possibility that this 'lapse' wasn’t actually a mistake after all…. The theory advanced by its proponents is that in attempt to spice up their hotel offering, Travelodge’s Marketing Development Department (TMDD) have come up with a ‘blind date’ type scheme whereby rooms occupied by single travellers are selected at random and a surprise additional occupant, also selected at random, is issued with a second pass key. Presumably neither 'victim' is aware of what the hotel (or fate!) has in store for them.... This scheme is apparently designed to ‘make life more interes...
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